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To validate both efficacy and safety, future investigations must employ robust disease models, elucidate molecular mechanisms, and conduct well-controlled, double-blind, randomized trials with standardized interventions and long-term follow-up

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Radical species include superoxide radical (O2_), hydroxyl radical (OH), alkoxyl (RO) and peroxyl (ROO) while non- radical species contains hydrogen peroxide (H2O2), singlet oxygen (1O2), ozone (O3), and hypochlorous acid (HClO)

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